MCM7 polyclonal, anti-human, mouse
€388.00
In stock
SKU
BS6169
Background:
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage
Alternative Name:
DNA replication licensing factor MCM7, CDC47 homolog, P1.1-MCM3, MCM7, CDC47, MCM2
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MCM7 polyclonal antibody detects endogenous levels of MCM7 protein.
Immunogen:
Recombinant full length Human MCM7.
MW: ~ 80 kDa
Swis Prot.: P33993
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for S-phase checkpoint activation upon UV-induced damage
Alternative Name:
DNA replication licensing factor MCM7, CDC47 homolog, P1.1-MCM3, MCM7, CDC47, MCM2
Application Dilution: WB: 1:500~1:2000, IF: 1:50~1:200
Specificity: MCM7 polyclonal antibody detects endogenous levels of MCM7 protein.
Immunogen:
Recombinant full length Human MCM7.
MW: ~ 80 kDa
Swis Prot.: P33993
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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