MCM7 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
MCM7(Minichromosome Maintenance, s. Cerevisiae, homolog of, 7), also called CDC47, FORMERLY, is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The MCM7 gene is mapped to 7q22.1. MCM7 plays a pivotal role in the G1/S phase transition, orchestrating the correct assembly of replication forks on chromosomal DNA and ensuring that all the genome is replicated once and not more than once at each cell cycle. The MCM7 gene contains 15 exons. The miRNAs MIR106B, MIR93, and MIR25 are clustered in a 5-prime to 3-prime orientation within intron 13. It has been found that MCM7 and the precursors of microRNAs (miRNAs) MIR106B, MIR93, and MIR25, all of which arise from intron 13 of the MCM7 gene, were overexpressed with almost perfect correlation in 5 of 10 human gastric tumors.

Description:
Rabbit IgG polyclonal antibody for DNA replication licensing factor MCM7 (MCM7) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
CDABP0042 antibody, CDC 47 antibody, CDC47 antibody, CDC47 homolog antibody, Cdc47, S. cerevisiae, homolog of antibody, DNA replication licensing factor MCM7 antibody, Homolog of S. cerevisiae Cdc47 antibody, MCM 2 antibody, MCM 7 antibody, MCM2 antibody, MCM2, formerly antibody, Mcm7 antibody, MCM7 minichromosome maintenance deficient 7 antibody, MCM7_HUMAN antibody, Minichromosome Maintainence 7 antibody, Minichromosome maintainence, S. cerevisiae, homolog of antibody, Minichromosome maintenance complex component 7 antibody, Minichromosome maintenance deficient 7 antibody, Minichromosome maintenance protein 7 antibody, P1.1 MCM3 antibody, P1.1-MCM3 antibody, P1CDC47 antibody, P85MCM antibody, PNAS 146 antibody, PNAS146 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human MCM7 recombinant protein (Position: D526-V719). Human MCM7 shares 94% amino acid (aa) sequence identity with mouse MCM7.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.