MCM8 polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS60306
Background:
The mini-chromosome maintenance (MCM) family of proteins include MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5), MCM7 (Cdc47), MCM8, MCM9 and MCM10 (Dna43). The proteins in this family are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. MCM proteins are crucial components of the pre-replication complex (pre-RC) and are involved in replication fork formation and the recruitment of other DNA replication proteins. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP- dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. Throughout the cell cycle, MCM8 binds chromatin. MCM8 can interact with CDC6 and ORC2L.
Alternative Name:
DNA helicase MCM8, Minichromosome maintenance 8 , MCM8, C20orf154
Application Dilution: WB: 1:500~1:1000
Specificity: MCM8 polyclonal antibody detects endogenous levels of MCM8protein.
Immunogen:
A synthetic peptide corresponding to residues in Human MCM8.
MW: ~ 94 kDa
Swis Prot.: Q9UJA3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The mini-chromosome maintenance (MCM) family of proteins include MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5), MCM7 (Cdc47), MCM8, MCM9 and MCM10 (Dna43). The proteins in this family are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. MCM proteins are crucial components of the pre-replication complex (pre-RC) and are involved in replication fork formation and the recruitment of other DNA replication proteins. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP- dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. Throughout the cell cycle, MCM8 binds chromatin. MCM8 can interact with CDC6 and ORC2L.
Alternative Name:
DNA helicase MCM8, Minichromosome maintenance 8 , MCM8, C20orf154
Application Dilution: WB: 1:500~1:1000
Specificity: MCM8 polyclonal antibody detects endogenous levels of MCM8protein.
Immunogen:
A synthetic peptide corresponding to residues in Human MCM8.
MW: ~ 94 kDa
Swis Prot.: Q9UJA3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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