MCPIP1 polyclonal, anti-human

Background:
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL) (By similarity).

Synonyms: dJ423B22.1, MCPIP, MCPIP1, dJ423B22.1, MCPIP, MCPIP-1, MCPIP1, Reg1

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human MCPIP1

Gene Symbol: MCPIP1

Gene ID: 80149

Swiss prot: Q5D1E8

Calculated MW: 67kDa

Recommended dilution:
WB 1:500-2000, IHC 1:20-50,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.