MDM2 (phospho-S166) polyclonal, anti-human, mouse, rat

Background:
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

Synonyms: ACTFS, HDMX, hdm2

Cellular Location: Cytoplasm Nucleus nucleolus nucleoplasm

Immunogen:
A phospho specific peptide corresponding to residues surrounding S166 of human MDM2

Gene Symbol: Phospho-MDM2-S166

Gene ID: 4193

Swiss prot: Q00987

Calculated MW: 55kDa

Recommended dilution:
WB 1:500-1000, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.