MDM2 polyclonal, anti-human, mouse, rat, chimpanzee, monkey, rabbit, guinea pig, pig, cat, dog, horse, bovine
€445.00
In stock
SKU
254518
Protein Family: Transporters, Enzymes, Ubiquitins
Pathway and Disease: Cancers
Description:
MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1, permits the nuclear export of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.
Alternate Names: MDM2, E3 ubiquitin-protein ligase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2
Application Notes: E: 1:10,000-1:20,000; WB: 1:5,000-1:10,000
Accession No.: Q00987
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.05% sodium azide and 0.05% thimerosal. Antibody was purified by antigen-affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Cancers
Description:
MDM2 mediates ubiquitination of p53/TP53, leading to its degration by the proteasome. MDM2 inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding to their respective transcriptional activation domains. MDM2 also acts as an ubiquitin ligase towards itself and ARRB1, permits the nuclear export of TP53/p53, and promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein.
Alternate Names: MDM2, E3 ubiquitin-protein ligase Mdm2, p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2
Application Notes: E: 1:10,000-1:20,000; WB: 1:5,000-1:10,000
Accession No.: Q00987
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human MDM2.
Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.05% sodium azide and 0.05% thimerosal. Antibody was purified by antigen-affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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