MDM4 Antibody (Center) Blocking peptide
€363.00
In stock
SKU
AC-BP13861c
Background:
The human MDM4 gene, which plays a role in apoptosis,encodes a 490-amino acid protein containing a RING finger domainand a putative nuclear localization signal. The MDM4 putativenuclear localization signal, which all Mdm proteins contain, islocated in the C-terminal region of the protein. The mRNA isexpressed at a high level in thymus and at lower levels in allother tissues tested. MDM4 protein produced by in vitro translationinteracts with p53 via a binding domain located in the N-terminalregion of the MDM4 protein. MDM4 shows significant structuralsimilarity to p53-binding protein MDM2. Two transcript variants,one protein-coding and the other likely not to be protein-coding,have been found for this gene.
Other Names:
Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13861c was selected from the Center region of MDM4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MDM4
Gene ID: 4194
Primary Accession: O15151
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The human MDM4 gene, which plays a role in apoptosis,encodes a 490-amino acid protein containing a RING finger domainand a putative nuclear localization signal. The MDM4 putativenuclear localization signal, which all Mdm proteins contain, islocated in the C-terminal region of the protein. The mRNA isexpressed at a high level in thymus and at lower levels in allother tissues tested. MDM4 protein produced by in vitro translationinteracts with p53 via a binding domain located in the N-terminalregion of the MDM4 protein. MDM4 shows significant structuralsimilarity to p53-binding protein MDM2. Two transcript variants,one protein-coding and the other likely not to be protein-coding,have been found for this gene.
Other Names:
Protein Mdm4, Double minute 4 protein, Mdm2-like p53-binding protein, Protein Mdmx, p53-binding protein Mdm4, MDM4, MDMX
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP13861c was selected from the Center region of MDM4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MDM4
Gene ID: 4194
Primary Accession: O15151
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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