MDR1/ABCB1/P-Glycoprotein [clone EP271], anti-human

Description: The multidrug resistance protein 1 (MDR-1), also known as P-glycoprotein 1 (PgP), is a conserved plasma membrane protein that functions as an ATP-dependent efflux pump with broad specificity. MDR-1 expression is thought to cause cross-resistance to structurally unrelated anti-cancer drugs, which may decrease intracellular drug concentrations. MDR-1 is typically expressed primarily in regions that act as epithelial barriers or perform excretory function in the liver, kidney, gastrointestinal tract, and the blood-brain barrier. In tumors, MDR-1 is widely expressed in many human cancers, commonly found in colon cancer, renal cancer, hepatocellular carcinoma and hematopoietic malignancies.Localization: membraneDilution: 50-200Positive Control: HCC, brain, kidneyHIER: citrate pH6.0 or EDTA pH8.0Status: RUO