MECOM Polyclonal Antibody

Background:
The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Ecotropic Virus Integration Site 1 Protein Homolog, MDS1 And EVI1 Complex Locus Protein, PR Domain 3, EVI1, MDS1, MDS1 And EVI1 Complex Locus Protein EVI1, MDS1 And EVI1 Complex Locus Protein MDS1, Ecotropic Viral Integration Site 1, Myelodysplasia Syndrome 1 Protein, Zinc Finger Protein Evi1, Oncogene EVI1, AML1-EVI-1, MDS1-EVI1, RUSAT2, KMT8E, PRDM3

Immunogen: Synthetic peptide of human MECOM

Swissprot: Q03112
Gene Accession: NP005232

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.68 mg/mL
Dilution: IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.