MeCP2 polyclonal , anti-human, mouse
€0.00
In stock
SKU
AC-AP2545d
Catalog Number: AC-AP2545d
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB25959
Applications: IHC-P-Leica, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB25959
Applications: IHC-P-Leica, WB
Datasheet
Request Information
Background:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Other Names:
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Target/Specificity:
This MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-428 amino acids from human MeCP2.
Antigen Region:
400-428
Antigen Type: Synthetic Peptide
Gene Name: MECP2
Gene ID: 4204
Primary Accession: P51608
Other Accession: Q95LG8
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
Other Names:
Methyl-CpG-binding protein 2, MeCp-2 protein, MeCp2, MECP2
Target/Specificity:
This MeCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 400-428 amino acids from human MeCP2.
Antigen Region:
400-428
Antigen Type: Synthetic Peptide
Gene Name: MECP2
Gene ID: 4204
Primary Accession: P51608
Other Accession: Q95LG8
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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