MECP2 Polyclonal Antibody

Background:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
AUTSX 3, AUTSX3, DKFZp686A24160, Mbd 5, Mbd5, MECP 2, MeCP 2 protein, MeCP-2 protein, Mecp2, MECP2, Methyl CpG binding protein 2 (Rett syndrome), Methyl CpG binding protein 2, Methyl-CpG-binding protein 2, MRX 16, MRX 79, MRX16, MRX79, MRXS 13, MRXS13, MRXSL, PPMX, RS, RTS, RTT, WBP 10, WBP10

Immunogen: Recombinant protein of human MECP2

Swissprot: P51608
Gene Accession: BC011612

Calculated MW: 52 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.5 mg/mL
Dilution: WB 1:200-1:1000, IHC 1:100-1:300

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-5758/sc-5755/sc-20700