MEF2C polyclonal, anti-human antibody
€310.00
In stock
SKU
AC-ABV11665-100
Catalog Number: AC-ABV11665-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF
Datasheet
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Size: 100 µl
Host: Rabbit IgG
Applications: WB, IHC, IF
Datasheet
Request Information
Background:
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Other Names:
Myocyte-specific enhancer factor 2C, MEF2C
Primary Accession: Q06413
Gene Name: MEF2C (HGNC:6996)
Gene ID: 4208
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
Other Names:
Myocyte-specific enhancer factor 2C, MEF2C
Primary Accession: Q06413
Gene Name: MEF2C (HGNC:6996)
Gene ID: 4208
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