MEK-2 (phospho Thr394) polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Synonyms: MAP2K2, MEK2, MKK2, PRKMK2, Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2

Cellular Location: Cytoplasm Membrane

Immunogen:
A synthetic peptide of human MEK2 (phospho Thr394)

Gene Symbol: MEK-2 (phospho Thr394)

Gene ID: 5605

Swiss prot: P36507

Calculated MW: 44kDa

Recommended dilution:
WB 1:500-1:2000, IHC 1:100-1:300, IP 1:200-1:500, ELISA 1:10000,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.