MEK Kinase-6 rabbit polyclonal, anti-human, mouse

Backgroud: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Activated by phosphorylation on Thr-806. Catalytically active only when complexed with MAP3K5, with MAP3K5 supporting the stability and the active configuration of MAP3K6 and MAP3K6 activating MAP3K5 by direct phosphorylation.,function:Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Binds both upstream activators and downstream substrates in multimolecular complexes.,

Synonyms: MAP3K6, ASK2, MAPKKK6, MEKK6, Mitogen-activated protein kinase kinase kinase 6, Apoptosis signal-regulating kinase 2

Gene Name: MAP3K6

Gene ID: 9064

SwissProt ID: O95382

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.