MEK3/6 polyclonal, anti-human, mouse, rat

Background:
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Alternative Name:
MAP kinase kinase 3, MAPKK 3, MEK 3, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, MAP kinase kinase 6, MAPKK 6, MEK 6, SAPK kinase 3, SAPKK-3, SAPKK3, MAP2K6, Dual specificity mitogen activated protein kinase kinase 6, Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAP kinase kinase 6, map2k3, MAP2K6, MAPK/ERK kinase 3, MAPK/ERK kinase 6, MAPKK 3, MAPKK 6, MAPKK3, MAPKK6, MEK 3, MEK 6, Mitogen activated protein kinase kinase 3, Mitogen activated protein kinase kinase 6, MKK3, MKK6, MP2K3, PRKMK3, PRKMK6, Protein kinase, mitogen activated, kinase 6 (MAP kinase kinase 6), SAPK kinase 2, SAPKK 3, SAPKK-2, SAPKK2, SAPKK3, Stress activated protein kinase kinase 3, Stress-activated protein kinase kinase 2,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: MEK3/6 polyclonal antibody detects endogenous levels of MEK3/6 protein.

Immunogen:
recombinant protein

MW: 39/37 kDa

Swiss-Prot: P46734(Human) P52564(Human) O09110(Mouse) P70236(Mouse) EntrezGene:114495(Rat) EntrezGene:303200(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.