MEK3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al.(1997) localized the MAP2K3 gene to 17q11.2.

Description:
Rabbit IgG polyclonal antibody for Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
AW212142 antibody, Dual specificity mitogen activated protein kinase kinase 3 antibody, Dual specificity mitogen-activated protein kinase kinase 3 antibody, ERK kinase 3 antibody, MAP kinase kinase 3 antibody, MAP2K 3 antibody, map2k3 antibody, MAPK ERK kinase 3 antibody, MAPK kinase 3 antibody, MAPK/ERK kinase 3 antibody, MAPKK 3 antibody, MAPKK3 antibody, MEK 3 antibody, MEK3 antibody, Mitogen activated protein kinase kinase 3 antibody, MKK 3 antibody, MKK3 antibody, mMKK 3b antibody, mMKK3b antibody, MP2K3_HUMAN antibody, MPK 3 antibody, PRKMK 3 antibody, PRKMK3 antibody, Protein kinase mitogen activated kinase 3 antibody, protein kinase, mitogen-activated, kinase 3 antibody, SAPK kinase 2 antibody, SAPKK 2 antibody, SAPKK2 antibody, SKK2 antibody, Stress activated protein kinase kinase 2 antibody, zMKK 3 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human MEK3(42-58aa RNLDSRTFITIGDRNFE), identical to the related mouse and rat sequences.A synthetic peptide corresponding to a sequence at the N-terminus of human MEK3(42-58aa RNLDSRTFITIGDRNFE), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.