MEK3 polyclonal, anti-human, mouse, rat

Background:
A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Alternative Name:
MAP kinase kinase 3, MAPKK 3, MEK 3, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3, AW212142, dual specificity mitogen activated protein kinase kinase 3, Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, map2k3, MAPK ERK kinase 3, MAPK/ERK kinase 3, MAPKK 3, MAPKK3, MEK 3, MEK3, Mitogen activated protein kinase kinase 3, MKK 3, MKK3, mMKK3b, MP2K3, PRKMK 3, PRKMK3, protein kinase, mitogen-activated, kinase 3, SAPK kinase 2, SAPKK 2, SAPKK2, Stress activated protein kinase kinase 2,

Application Dilution:
WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: MEK3 polyclonal antibody detects endogenous levels of MEK3 protein.

Immunogen:
recombinant protein

MW: 39 kDa

Swiss-Prot: P46734(Human) O09110(Mouse) Unigene:100064(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.