MEK4 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Dual specificity mitogen-activated protein kinase kinase 4(MAP2K4), also called SEK1 or JNKK1, is an enzyme that in humans is encoded by the MAP2K4 gene. It is mapped to 17p12. This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK1. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. MAP2K4 was a specific activator of JNK1, JNK2, and p38, and it has been shown to interact with FLNC, MAPK8, MAPK8IP3 and AKT1.

Description:
Rabbit IgG polyclonal antibody for Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
c Jun N terminal kinase kinase 1 antibody, C-JUN N-terminal kinase kinase 1 antibody, Dual specificity mitogen activated protein kinase kinase 4 antibody, Dual specificity mitogen-activated protein kinase kinase 4 antibody, JNK Activated Kinase 1 antibody, JNK activating kinase 1 antibody, JNK-activating kinase 1 antibody, JNKK antibody, JNKK1 antibody, MAP kinase kinase 4 antibody, Map2k4 antibody, MAPK ERK kinase 4 antibody, MAPK/ERK kinase 4 antibody, MAPKK 4 antibody, MAPKK4 antibody, MEK 4 antibody, MEK4 antibody, Mitogen activated protein kinase kinase 4 antibody, MKK 4 antibody, MKK4 antibody, PRKMK4 antibody, SAPK ERK kinase 1 antibody, SAPK/ERK kinase 1 antibody, SEK1 antibody, SERK1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human MEK4(360-378aa ELLKHPFILMYEERAVEVA), different from the related mouse and rat sequences by one amino acid.A synthetic peptide corresponding to a sequence at the C-terminus of human MEK4(360-378aa ELLKHPFILMYEERAVEVA), different from the related mouse and rat sequences by one amino acid.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat .
Predicted to work with: mouse.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.