MEKK4 Antibody (Center C1081) Blocking Peptide
€363.00
In stock
SKU
AC-BP14786c
Background:
The central core of each mitogen-activated protein kinase(MAPK) pathway is a conserved cascade of 3 protein kinases: anactivated MAPK kinase kinase (MAPKKK) phosphorylates and activatesa specific MAPK kinase (MAPKK), which then activates a specificMAPK. While the ERK MAPKs are activated by mitogenic stimulation,the CSBP2 and JNK MAPKs are activated by environmental stressessuch as osmotic shock, UV irradiation, wound stress, andinflammatory factors. This gene encodes a MAPKKK, the MEKK4protein, also called MTK1. This protein contains a protein kinasecatalytic domain at the C terminus. The N-terminal nonkinase domainmay contain a regulatory domain. Expression of MEKK4 in mammaliancells activated the CSBP2 and JNK MAPK pathways, but not the ERKpathway. In vitro kinase studies indicated that recombinant MEKK4can specifically phosphorylate and activate PRKMK6 and SERK1,MAPKKs that activate CSBP2 and JNK, respectively but cannotphosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is amajor mediator of environmental stresses that activate the CSBP2MAPK pathway, and a minor mediator of the JNK pathway. Twoalternatively spliced transcripts encoding distinct isoforms havebeen described.
Other Names:
Mitogen-activated protein kinase kinase kinase 4, MAP three kinase 1, MAPK/ERK kinase kinase 4, MEK kinase 4, MEKK 4, MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Gene Name: MAP3K4
Gene ID: 4216
Primary Accession: Q9Y6R4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The central core of each mitogen-activated protein kinase(MAPK) pathway is a conserved cascade of 3 protein kinases: anactivated MAPK kinase kinase (MAPKKK) phosphorylates and activatesa specific MAPK kinase (MAPKK), which then activates a specificMAPK. While the ERK MAPKs are activated by mitogenic stimulation,the CSBP2 and JNK MAPKs are activated by environmental stressessuch as osmotic shock, UV irradiation, wound stress, andinflammatory factors. This gene encodes a MAPKKK, the MEKK4protein, also called MTK1. This protein contains a protein kinasecatalytic domain at the C terminus. The N-terminal nonkinase domainmay contain a regulatory domain. Expression of MEKK4 in mammaliancells activated the CSBP2 and JNK MAPK pathways, but not the ERKpathway. In vitro kinase studies indicated that recombinant MEKK4can specifically phosphorylate and activate PRKMK6 and SERK1,MAPKKs that activate CSBP2 and JNK, respectively but cannotphosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is amajor mediator of environmental stresses that activate the CSBP2MAPK pathway, and a minor mediator of the JNK pathway. Twoalternatively spliced transcripts encoding distinct isoforms havebeen described.
Other Names:
Mitogen-activated protein kinase kinase kinase 4, MAP three kinase 1, MAPK/ERK kinase kinase 4, MEK kinase 4, MEKK 4, MAP3K4, KIAA0213, MAPKKK4, MEKK4, MTK1
Gene Name: MAP3K4
Gene ID: 4216
Primary Accession: Q9Y6R4
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review