Menin polyclonal, anti-human, mouse

Quantity: 100 µg

Background:
The MEN1 gene encodes menin, a nuclear scaffold protein that regulates gene transcription by coordinating chromatin remodeling. It is mapped to 11q13.1. MEN1 is considered to act as a tumor suppressor gene. It has been found that that MEN1 inactivation by antisense RNA antagonizes transforming growth factor-beta-mediated cell growth inhibition. Overexpression of MEN1 in an inducible cell culture system downregulated the proximal promoter. In vitro studies have shown that MEN1 is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcriptional activation by JunD. What’s more, MEN1 was essential to maintain MLL-associated myeloid transformation.

Description:
Rabbit IgG polyclonal antibody for Menin (MEN1) detection. Tested with WB in Human, Mouse.

Synonyms:
MEA 1 antibody, MEA1 antibody, MEN 1 antibody, MEN1 antibody, MEN1_HUMAN antibody, Menin antibody, Multiple Endocrine Adenomatosis 1 antibody, Multiple Endocrine Neoplasia 1 antibody, SCG 2 antibody, SCG2 antibody, Suppressor Candidate Gene 2 antibody, Wermer syndrome antibody, ZES antibody, Zollinger Ellison Syndrome antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Menin recombinant protein (Position: P301-L615). Human Menin shares 93% and 94% amino acid (aa) sequence identity with mouse and rat Menin, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.