Mes-4 Antibody (C-term) Blocking Peptide

Background:
Mes-4 is a histone methyltransferase. This protein dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Mes-4 plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. It appears to be indirectly involved in the global inactivation of the X chromosomes in germ line cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes.

Other Names:
Histone-lysine N-methyltransferase mes-4, Maternal-effect sterile protein 4, mes-4

Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1965b was selected from the C-term region of human Mes-4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Gene Name: mes-4 {ECO:0000312|WormBase:Y2H9A.1}

Gene ID: 179824
Primary Accession: Q9NH52
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.