Metadherin (clone 2F11C3), anti-human

Protein Family: Transcription Factors

Pathway and Disease: Transcription, Cell Growth and Death

Description:
Metadherin (Metastasis adhesion protein) localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Alternate Names: Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, AEG-1, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein AEG1, LYRIC, MTDH

Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000; FC: 1:200-1:400

Accession No.: Q86UE4

Antigen: Purified recombinant fragment of human MTDH expressed in E. coli.

Format: Each vial contains 0.1 ml IgG in PBS pH7.4, 50% glycerol with 0.03% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.