METAP2 polyclonal, anti-human, mouse, rat

Background:
Methionine aminopeptidases (MetAP), also designated peptidase M proteins, are members of the M24 family of proteins. Both MetAP-1 and MetAP-2 release N-terminal amino acids, usually methionine, from nascent peptides and arylamines. Eukaryotes contain both MetAP-1 and MetAP-2, whereas prokaryotes possess only the MetAP-1 enzyme. MetAP-1 and MetAP-2 control cell proliferation in mammalian cells. MetAP-2 is highly conserved between human and Saccharomyces cerevisiae. Neurofibromin (NF1) regulates MetAp-2 and increased expression of MetAP-2 correlates with several forms of cancer. Inhibitors of MetAP-2 are potential targets in cancer therapeutics, particularly in NF1-associated tumor proliferation. Chemotherapeutic drugs such as ovalicin and fumagillin bind to the active site of and inhibit MetAp-2.

Alternative Name:
MAP 2, MetAP 2, p67, p67eIF2, METAP2, MNPEP, P67EIF2, A930035J23Rik, AI047573, AL024412, Amp2, AU014659, , EIF 2 associated p67 homolog, EIF-2-associated p67, Initiation factor 2 associated 67 kDa glycoprotein, Initiation factor 2-associated 67 kDa glycoprotein, MAP 2, MAP2, MAP2, MetAP 2, Metap2, Methionine aminopeptidase 2, Methionyl aminopeptidase 2, MGC102452, MGC127390, MGC53792, MNPEP, p67, p67eIF2, Peptidase M, Peptidase M2,

Application Dilution:
WB:1:500-1:2,000
ICC/IF:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100

Specificity: METAP2 polyclonal antibody detects endogenous levels of METAP2 protein.

Immunogen:
Recombinant protein within C-terminal human Methionine Aminopeptidase 2.

MW: Predicted band size 53 kDa

Swiss-Prot: P50579(Human) O08663(Mouse) P38062(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.