METTL7A Polyclonal Antibody

Background:
METTL7A (methyltransferase like 7A), also known as AAM-B, is a 244 amino acid protein that is thought to function as a methyltransferase and is encoded by a gene which maps to chromosome 12. Encoding over 1, 100 genes, chromosome 12 comprises nearly 4.5% of the human genome and is associated with a number of skeletal deformaties, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to both a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and a natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Additionally, Trisomy 12p (three copies of the p arm of chromosome 12) leads to facial developmental defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism.

Research Area: Epigenetics and Nuclear Signaling

Synonyms:
AAM B, AAMB, DKFZP586A0522, MET7A, Methyltransferase like 7A, Methyltransferase-like protein 7A, METTL 7A, METTL7A, METTL7A methlytransferase like 7A, Protein AAM-B, Protein AAMB

Immunogen: Fusion protein of human METTL7A

Swissprot: Q9H8H3
Gene Accession: BC004492

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.