MFN2 Polyclonal Antibody

Background:
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.

Research Area: Cancer, Cell Biology, Metabolism, Neuroscience, Signal Transduction, Tags and Cell Markers

Synonyms:
CMT2A, CMT2A2, CPRP 1, CPRP1, EC 3.6.5.-, Fzo, HSG, hyperplasia suppressor gene, Hypertension related protein 1, KIAA0214, MARF, MFN 2, Mfn2, MFN2, Mitochondrial assembly regulatory factor, Mitofusin-2, Mitofusin2, Transmembrane GTPase MFN2

Immunogen: Synthesized peptide derived from the Internal region of human Mfn2.

Swissprot: O95140

Calculated MW: 86 kDa
Observed MW: 86 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:40000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-30366/sc-50331