mGluR-5 (clone ) , anti-human, mouse, rat

Background:
The mGluR proteins (metabotropic glutamate receptors) are members of the G protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR-1 and mGluR-5 are mediated by a G protein that activates a phosphatidylinositolcalcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight subtypes of mGluR have an activity mediated by a G protein that inhibits adenylate cyclase activity. mGluR-3, which may interact with GRASP, acts as a receptor for glutamate.

Alternative Name:
Metabotropic glutamate receptor 5, mGluR5, GRM5, GPRC1E, MGLUR5

Application Dilution: WB: 1:1000-1:2000, ICC/IF: 1:50-1:200, IHC: 1:200-1:500, FC: 1:50-1:100

Specificity: This antibody detects endogenous levels of mGluR-5 and does not cross-react with related proteins.

Immunogen:
Recombinant antibody.

MW: ~ 132 kDa

Swis Prot.: P41594

Purification & Purity:
Protein A affinity purified

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.