mGluR5/1 polyclonal, anti-human, mouse, rat

Protein Family: Receptors and Channels

Pathway and Disease: Nervous and Sensory Systems, Neurodegenerative Disorders, Cell Communication, Signaling Molecules and Interaction, Signal Transduction

Description:
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse. Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. The mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus. This antibody detects both mGluR1 and mGluR5.

Alternate Names: Metabotropic glutamate receptor 5, mGluR5, m5, Gprc1e, Mglur5, GRM1, Metabotropic glutamate receptor 1, mGluR1, GPRC1A 

Application Notes: E: 1:500-1:1,000; WB: 1:1,000; IHC : 1:500

Accession No.: P31424, P23385

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of rat mGluR5/1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of HEPES (pH7.5), 0.01% BSA, with 50% glycerol. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.