mGluR5 rabbit polyclonal, anti-human, mouse, rat

Backgroud: glutamate metabotropic receptor 5(GRM5) Homo sapiens This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014],function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current.,similarity:Belongs to the G-protein coupled receptor 3 family.,subunit:The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP.,

Synonyms: GRM5, GPRC1E, MGLUR5, Metabotropic glutamate receptor 5, mGluR5

Gene Name: GRM5

Gene ID: 2915

SwissProt ID: P41594

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.