MGP Polyclonal Antibody

Background:
Matrix Gla protein (MGP) is is a vitamin K-dependent, extracellular matrix protein. MGP plays a pivotal role in preventing soft tissue calcification and local mineralization of the vascular wall. Vitamin K deficiency leads to inactive uncarboxylated MGP (ucMGP), which accumulates at sites of arterial calcification. However MGP is synthesized in many tissues and is especially enriched in embryonic tissues and in cancer cells. Defects in MGP are the cause of Keutel syndrome (KS), which is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.

Research Area: Signal Transduction

Synonyms:
Cell growth inhibiting gene 36 protein, Cell growth-inhibiting gene 36 protein, GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX, GIG36, Matrix Gla protein, MGLAP, MGP, MGP, NTI

Immunogen: Fusion protein of human MGP

Swissprot: P08493
Gene Accession: BC005272

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.32 mg/mL
Dilution: IHC 1:70-1:350, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.