MHC I A,B,C (clone Bra23/9), anti-human

Source:
A BALB/c mouse was immunized with non-T, non-B human acute lymphoblastic leukemia REH6 cells.
Fusion partner: NS-1.

Specifications:
Bra23/9 reacts with a monomorphic determinant of human major histocompatibility (MHC) class I antigens (HLA-A, B and C). Human MHC class I antigens are expressed constitutively on all nucleated cells and platelets and are absent on erythrocytes. MHC class I antigens play a role in class I MHC-associated antigen presentation, inhibition of NK cell cytotoxicity, tumor surveillance, and tissue allotransplantation.

Species reactivity:
Positive: human.

Applications:
Demonstration of MHC I A, B, C.
Frozen sections<: +br />Flow cytometry: +
ELISA
Immunoprecipitation: +

Positive control: THP-1 and Jurkat cells. Tonsil or lymph node.

References:
- Chorváth et al., Neoplasma35(5): 495-501 (1988).
- Plesková et al., Neoplasma35(6): 657-664 (1988).
- Chorváth et al., Neoplasma37(3): 317-331 (1990)