MHC II (mouse) (I-A region) (clone IBL-5/22), anti-mouse

Source:
A Wistar rat was immunized with mouse lymph node cells.
Fusion partner: Sp2/0-Ag14.

Specifications:
IBL-5/22 specifically detects mouse I-A MHC Class II. MHC Class II molecules bind to CD4 during interaction of CD4+ T-cells with antigen-presenting cells or with target cells.

Species reactivity:
Positive: mouse. Negative: human.

Applications:
Demonstration of I-A MHC Class II in mouse.
Flow cytometry: +
Frozen sections: +
Immunofluorescence: +
Immunoprecipitation: +
Paraffin sections: +
Western blot: +

Positive control: Mouse spleen.

References:
- Butovsky, O, et al.Proc Natl Acad Sci U S A.103(31): 11784-9 (2006).
- Gennari F, et al, Hum Gene Ther. 20(6): 554-62 (2009).
- Adams AE et al, Biochim Biophys Acta1777: 772-6 (2008).
- Shin, TS, et al, Allergy65: 1256-1265 (2010).
- Rodríguez-Prados, JC, et al. J. Immunol.185: 605-614 (2010).
- Hinterberger, M., et al.Nat. Immunol.11: 512-519 (2010).