MID1 antibody (clone 2C11), anti-human
€435.00
In stock
SKU
AC-AT2869a
Catalog Number: AC-AT2869a
Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB
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Size: 100 µg
Isotype: mouse IgG2b Kappa
Applications: WB
Request Information AC-AT2869a">Request Information
Background:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined.
Other Names:
E3 ubiquitin-protein ligase Midline-1, 632-, Midin, Putative transcription factor XPRF, RING finger protein 59, RING finger protein Midline-1, Tripartite motif-containing protein 18, MID1, FXY, RNF59, TRIM18, XPRF
Antigen Type:
Recombinant Protein
Gene Name: MID1
Gene ID: 4281
NCBI Accession: NP_000372.1;NP_001092094.1;NP_001180206.1;NP_001180207.1;NP_001180208.1;NP_001180209.1;NP_001180210.1;NP_150632.1
Primary Accession: O15344
Other Accession: BC053626
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Multiple different transcript variants are generated by alternate splicing; however, the full-length nature of some of the variants has not been determined.
Other Names:
E3 ubiquitin-protein ligase Midline-1, 632-, Midin, Putative transcription factor XPRF, RING finger protein 59, RING finger protein Midline-1, Tripartite motif-containing protein 18, MID1, FXY, RNF59, TRIM18, XPRF
Antigen Type:
Recombinant Protein
Gene Name: MID1
Gene ID: 4281
NCBI Accession: NP_000372.1;NP_001092094.1;NP_001180206.1;NP_001180207.1;NP_001180208.1;NP_001180209.1;NP_001180210.1;NP_150632.1
Primary Accession: O15344
Other Accession: BC053626
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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