Midkine polyclonal, anti-human

Quantity: 100 µg

Background:
Midkine(MK or MDK), also known as neurite growth-promoting factor 2(NEGF2), is a protein that in humans is encoded by the MDK gene. Midkine is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin(NEGF1, 46% homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair. Midkine is pleiotropic, capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. A molecular complex containing receptor-type tyrosine phosphatase zeta(PTPζ), low density lipoprotein receptor-related protein(LRP1), anaplastic leukemia kinase (ALK) and syndecans is considered to be its receptor.

Description:
Rabbit IgG polyclonal antibody for Midkine (MDK) detection. Tested with WB in Human.

Synonyms:
Amphiregulin associated protein antibody, Amphiregulin-associated protein antibody, ARAP antibody, FLJ27379 antibody, MDK antibody, Midgestation and kidney protein antibody, Midkine antibody, MK 1 antibody, MK antibody, MK_HUMAN antibody, MK1 antibody, NEGF 2 antibody, NEGF2 antibody, neurite growth promoting factor 2 antibody, Neurite outgrowth promoting protein antibody, Neurite outgrowth-promoting factor 2 antibody, Neurite outgrowth-promoting protein antibody, Retinoic acid inducible factor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Midkine recombinant protein (Position: V21-D143). Human Midkine shares 87% and 89% amino acid (aa) sequence identity with mouse and rat Midkine, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.