Milk Fat Globule 1 polyclonal, anti-human

Quantity: 100 µg

Background:
MFGE8(Milk Fat Globule-Egf Factor 8), also called as Lactadherin or SED1, is a protein which in humans is encoded by the MFGE8 gene. Mfge8 is secreted protein found in vertebrates, including mammals as well as birds. By fluorescence in situ hybridization, Collins et al.(1997) mapped the MFGE8 gene to chromosome 15q25. Hanayama et al.(2002) found that MFGE8 is a factor that links apoptotic cells to phagocytes. MFGE8 specifically bound to apoptotic cells by recognizing aminophospholipids such as phosphatidylserine. MFGE8, when engaged by phospholipids, bound to cells via its RGD motif. It bound particularly strongly to cells expressing alpha-V-beta-3 integrin. Bu et al.(2007) showed that Mfge8 was expressed in intestinal lamina propria macrophages in mice. Using a wound-healing assay, they showed that Mfge8 promoted migration of intestinal epithelial cells through a PKC-epsilon(PRKCE)-dependent mechanism.

Description:
Rabbit IgG polyclonal antibody for Lactadherin (MFGE8) detection. Tested with WB, IHC-P in Human.

Synonyms:
BA 46 antibody, BA46 antibody, Breast epithelial antigen BA46 antibody, Contains Medin antibody, EDIL 1 antibody, EDIL1 antibody, HMFG antibody, hP47 antibody, HsT19888 antibody, Lactadherin antibody, Lactadherin precursor antibody, Medin antibody, MFG E8 antibody, MFG-E8 antibody, MFGE 8 antibody, MFGE8 antibody, MFGE8 protein antibody, MFGM antibody, MFGM_HUMAN antibody, Milk fat globule EGF factor 8 antibody, Milk fat globule EGF factor 8 protein antibody, Milk fat globule-EGF factor 8 antibody, O acetyl disialoganglioside synthase antibody, OAcGD3S antibody, SED1 antibody, SPAG10 antibody, Sperm associated antigen 10 antibody, Sperm surface protein hP47 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence in the middle region of human Human Milk Fat Globule 1(165-180aa NGHEFDFIHDVNKKHK).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.