MINA53 polyclonal, anti-human, mouse

Background:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.

Alternative Name:
ROX, MINA, 60S ribosomal protein L27a histidine hydroxylase, Bifunctional lysine specific demethylase and histidyl hydroxylase MINA, FLJ14393, Histone lysine demethylase MINA, MDIG, MINA, MINA, Mineral dust-induced gene protein, Myc induced nuclear antigen 53 kDa, MYC induced nuclear antigen, MYC-induced nuclear antigen, NO52, Nucleolar protein 52, Ribosomal oxygenase MINA, ROX,

Application Dilution:
WB:1:500-1:2,000
ICC:1:50-1:200

Specificity: MINA53 polyclonal antibody detects endogenous levels of MINA53 protein.

Immunogen:
recombinant protein

MW: 53 kDa

Swiss-Prot: Q8IUF8(Human) Q8CD15(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.