MIP-1β rabbit polyclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012],alternative products:CCL4L1 and CCL4L2 genes differ in their non-coding regions. Thus, alternative splicing events differ between the two genes,caution:Was originally (PubMed:9521068) thought to be a ligand for CCR8.,function:Chemokine that induces chemotaxis of cells expressing CCR5 or CCR1. Inhibits HIV replication in peripheral blood monocytes that express CCR5.,function:Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.,induction:By mitogens.,online information:Macrophage inflammatory protein entry,polymorphism:The copy number of the CC4L1 gene varies among individuals; most individuals have 1 to 6 copies in the diploid genome.,PTM:N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes.,similarity:Belongs to the intercrine beta (chemokine CC) family.,subunit:Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1-beta(3-69).,subunit:Interacts with CCR5.,tissue specificity:Detected in B-cells.,

Synonyms: CCL4, LAG1, MIP1B, SCYA4, C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta(1-69), Macrophage inflammatory protein 1-beta, MIP-1-beta, PAT 744, Protein H400, SIS-gamma, Small-inducible cytokine A4, T-cell activation protein 2, ACT-2

Gene Name: CCL4

Gene ID: 388372

SwissProt ID: P13236

Purification: Affinity purification

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.