MITF Polyclonal Antibody

Background:
This gene encodes a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. It regulates the differentiation and development of melanocytes retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Immunology

Synonyms:
MITF, CMM8, COMMAD, MI, WS2, WS2A, bHLHe32

Immunogen: Recombinant fusion protein of human MITF (NP_937801.1).

Swissprot: O75030
Gene ID: 4286

Calculated MW: 40 kDa/46 kDa/52 kDa/55 kDa/56 kDa/57 kDa/58 kDa
Observed MW: 65 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Citation(s):
https://www.sciencedirect.com/science/article/pii/S0923181120302000