Mitofusin 2 MFN2 monoclonal, anti-human, mouse, rat

Description: Anti-Mitofusin 2 MFN2 Rabbit Monoclonal Antibody . Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Protein Function:
Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions..

Other Names: Mitofusin-2, 3.6.5.-, Transmembrane GTPase MFN2, MFN2 {ECO:0000303|PubMed:12598526, ECO:0000312|HGNC:HGNC:16877}

Clone Name(s):
Clone: AOCA-13

Subcellular Localization: Mitochondrion outer membrane ; Multi- pass membrane protein. Colocalizes with BAX during apoptosis.

Tissue Specificity: Ubiquitous; expressed at low level. Highly expressed in heart and kidney..

Gene ID: 9927

Immunogen: A synthesized peptide derived from human Mitofusin 2

Calculated MW: 86402

Purification: Affinity-chromatography

Format: Liquid

Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.

Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.