MLF1 Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6716a
Background:
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6716a was selected from the N-term region of human MLF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MLF1
Gene ID: 4291
Primary Accession: P58340
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6716a was selected from the N-term region of human MLF1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MLF1
Gene ID: 4291
Primary Accession: P58340
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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