MLF1 polyclonal (C-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP6716b
Catalog Number: AC-AP6716b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18643
Applications: IHC-P, FC, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18643
Applications: IHC-P, FC, WB
Datasheet
Request Information
Background:
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Target/Specificity:
This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human MLF1.
Antigen Region:
215-244
Antigen Type: Synthetic Peptide
Gene Name: MLF1
Gene ID: 4291
Primary Accession: P58340
NCBI Accession: NP_001123628.1;NP_001123629.1;NP_001182361.1;NP_001182362.1;NP_001182363.1;NP_071888.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Target/Specificity:
This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-244 amino acids from the C-terminal region of human MLF1.
Antigen Region:
215-244
Antigen Type: Synthetic Peptide
Gene Name: MLF1
Gene ID: 4291
Primary Accession: P58340
NCBI Accession: NP_001123628.1;NP_001123629.1;NP_001182361.1;NP_001182362.1;NP_001182363.1;NP_071888.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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