MLF1 polyclonal (N-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP6716a
Catalog Number: AC-AP6716a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18642
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18642
Applications: WB
Datasheet
Request Information
Background:
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Target/Specificity:
This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human MLF1.
Antigen Region:
35-62
Antigen Type: Synthetic Peptide
Gene Name: MLF1
Gene ID: 4291
Primary Accession: P58340
NCBI Accession: NP_001123628.1;NP_001123629.1;NP_001182361.1;NP_001182362.1;NP_001182363.1;NP_071888.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
Other Names:
Myeloid leukemia factor 1, Myelodysplasia-myeloid leukemia factor 1, MLF1
Target/Specificity:
This MLF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-62 amino acids from the N-terminal region of human MLF1.
Antigen Region:
35-62
Antigen Type: Synthetic Peptide
Gene Name: MLF1
Gene ID: 4291
Primary Accession: P58340
NCBI Accession: NP_001123628.1;NP_001123629.1;NP_001182361.1;NP_001182362.1;NP_001182363.1;NP_071888.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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