MLK3 (phospho-T277/S281) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS64014
Background:
As a result of the binding of growth factors to their membrane receptors, cytoplasmic proteins containing Src homology 2 (SH2) domains associate with specific phosphotyrosine residues within the activated receptors and function as signaling intermediates. The action of such SH2 domain proteins frequently involves the activation of a second group of signaling intermediates characterized by SH3 domains. These latter proteins function through binding proline-rich sequences in target proteins. A novel human non-receptor protein kinase, designated either MLK3 or PTK1, is 847 amino acids in length and contains an SH3 domain in the absence of an SH2 domain. In addition, MLK3 is characterized by a leucine zipper basic region (a motif commonly associated with transcription factors) and has a long carboxy-terminal tail which exhibits proline-rich motifs similar to known SH3 binding sites. MLK3 is expressed widely and is related to the previously described MLK1 and MLK2 kinases.
Alternative Name:
Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11, MLK3, PTK1, SPRK
Application Dilution: WB: 1:500~1:1000
Specificity: p-MLK3 (T277/S281) polyclonal antibody detects endogenous levels of human MLK3 when phosphorylated at Thr602 and Ser281.
Immunogen:
Synthetic phosphopeptide derived from human MLK3 around the phosphorylation site of Threonine 277 and Serine281.
MW: ~ 93, 100 kDa
Swis Prot.: Q16584
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
As a result of the binding of growth factors to their membrane receptors, cytoplasmic proteins containing Src homology 2 (SH2) domains associate with specific phosphotyrosine residues within the activated receptors and function as signaling intermediates. The action of such SH2 domain proteins frequently involves the activation of a second group of signaling intermediates characterized by SH3 domains. These latter proteins function through binding proline-rich sequences in target proteins. A novel human non-receptor protein kinase, designated either MLK3 or PTK1, is 847 amino acids in length and contains an SH3 domain in the absence of an SH2 domain. In addition, MLK3 is characterized by a leucine zipper basic region (a motif commonly associated with transcription factors) and has a long carboxy-terminal tail which exhibits proline-rich motifs similar to known SH3 binding sites. MLK3 is expressed widely and is related to the previously described MLK1 and MLK2 kinases.
Alternative Name:
Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11, MLK3, PTK1, SPRK
Application Dilution: WB: 1:500~1:1000
Specificity: p-MLK3 (T277/S281) polyclonal antibody detects endogenous levels of human MLK3 when phosphorylated at Thr602 and Ser281.
Immunogen:
Synthetic phosphopeptide derived from human MLK3 around the phosphorylation site of Threonine 277 and Serine281.
MW: ~ 93, 100 kDa
Swis Prot.: Q16584
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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