MLK3 polyclonal, anti-human, mouse, rat antibody
€295.00
In stock
SKU
AC-ABV10314-100
Catalog Number: AC-ABV10314-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
MLK3 (Mixed lineage kinase 3) is a serine/threonine kinase that has an amino-terminal SH3 domain followed by the kinase domain and two leucine zippers, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. MLK3 functions as a MAPKKK of the SAPK/JNK stress pathway by directly phosphorylating SEK1/MKK4 and MKK7, altho µgh it is controversial whether MLK3 is involved in p38 stress pathway activation. MLK3 also functions as an IkB kinase and mediates the activation of the transcriptional factor NF-kB stimulated by CD3/CD28, s µggesting a role for MLK3 in immune and inflammatory responses.
Other Names:
MAP3K11 , MLK3 , SPRK , MLK-3 , PTK1 , MGC17114
Primary Accession: Q16584
Gene Name: MAP3K11 (HGNC:6850)
Gene ID: 4296
Concentration (mg/ml): 0.5 mg/ml
MLK3 (Mixed lineage kinase 3) is a serine/threonine kinase that has an amino-terminal SH3 domain followed by the kinase domain and two leucine zippers, a cdc42/Rac1 binding (CRIB) domain and several other domains/motifs at the carboxy-terminal region. MLK3 functions as a MAPKKK of the SAPK/JNK stress pathway by directly phosphorylating SEK1/MKK4 and MKK7, altho µgh it is controversial whether MLK3 is involved in p38 stress pathway activation. MLK3 also functions as an IkB kinase and mediates the activation of the transcriptional factor NF-kB stimulated by CD3/CD28, s µggesting a role for MLK3 in immune and inflammatory responses.
Other Names:
MAP3K11 , MLK3 , SPRK , MLK-3 , PTK1 , MGC17114
Primary Accession: Q16584
Gene Name: MAP3K11 (HGNC:6850)
Gene ID: 4296
Concentration (mg/ml): 0.5 mg/ml
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