MLK4 Antibody (Center) Blocking Peptide

Background:
Mixed-lineage kinases (MLKs) function as mitogen-activated protein kinase kinase kinases (MAP3Ks), activating the p38 and JNK signaling cascades. Systematic mutational analyses of tyrosine kinases reveal that a minimum of 30% of colorectal cancer contain at least one mutation in the tyrosine kinases; sampling of colorectal cancer cells suggest an important role for MLK4 in this process.

Other Names:
Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, MLK4 {ECO:0000303|Ref1}

Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP8006c was selected from the Center region of human MLK4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Gene Name: MAP3K21 (HGNC:29798)

Gene ID: 84451
Primary Accession: Q5TCX8
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.