MLKL (clone 5E3), anti-human

Backgroud: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Synonyms: MLKL

Gene Name: MLKL

Gene ID: 197259

SwissProt ID: Q8NB16

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.