MLKL monoclonal, anti-human
€455.00
In stock
SKU
AC-ABO13377
Catalog Number: AC-ABO13377
Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC
Datasheet
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Size: 100 µl
Isotype: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Description: Anti-MLKL Rabbit Monoclonal Antibody . Tested in WB, IHC applications. This antibody reacts with Human.
Protein Function:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity..
Other Names: Mixed lineage kinase domain-like protein, hMLKL, MLKL {ECO:0000303|PubMed:22265413, ECO:0000312|HGNC:HGNC:26617}
Clone Name(s):
Clone: DGB-13
Subcellular Localization: Cytoplasm. Cell membrane. Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Gene ID: 197259
Immunogen: A synthesized peptide derived from human MLKL
Calculated MW: 54479
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Protein Function:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity..
Other Names: Mixed lineage kinase domain-like protein, hMLKL, MLKL {ECO:0000303|PubMed:22265413, ECO:0000312|HGNC:HGNC:26617}
Clone Name(s):
Clone: DGB-13
Subcellular Localization: Cytoplasm. Cell membrane. Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.
Gene ID: 197259
Immunogen: A synthesized peptide derived from human MLKL
Calculated MW: 54479
Purification: Affinity-chromatography
Format: Liquid
Contents: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
Concentration (mg/ml): Actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
Storage: Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
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