MLKL (phospho-S345) polyclonal, anti-mouse

Background:
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.

Alternative Name:
Mlkl, 9130019I15Rik, FLJ34389, hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain like pseudokinase, Mixed lineage kinase domain-like protein, Mlkl, MLKL,

Application Dilution:
IHC:1:50-1:100

Specificity: MLKL (phospho-S345) polyclonal antibody detects endogenous levels of MLKL protein only when phosphorylated at S345.

Immunogen:
Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL.

MW: 54 kDa

Swiss-Prot: Q9D2Y4(Mouse)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.