MLL (clone 10F8D7), anti-human
€478.00
In stock
SKU
252749
Protein Family: Enzymes, Transcription factors
Pathway and Disease: Cancers, Development and Behavior
Description:
MLL (Histone-lysine N-methyltransferase) is a 430 kDa protein that regulates embryonal and hematopoietic development. Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.
Alternate Names: Histone-lysine N-methyltransferase MLL, ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like protein, Zinc finger protein HRX, MLL
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q03164
Antigen: Purified recombinant fragment of MLL (aa3751-3968) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
Pathway and Disease: Cancers, Development and Behavior
Description:
MLL (Histone-lysine N-methyltransferase) is a 430 kDa protein that regulates embryonal and hematopoietic development. Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary.
Alternate Names: Histone-lysine N-methyltransferase MLL, ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like protein, Zinc finger protein HRX, MLL
Application Notes: WB: 1:500-1:2000; IHC: 1:200-1:1000
Accession No.: Q03164
Antigen: Purified recombinant fragment of MLL (aa3751-3968) expressed in E. coli.
Format: Each vial contains 0.1 ml ascitic fluid with 0.03% sodium azide.
Storage:
Store at 4°C for short term use only. Store at -20°C for storage over 1 month. Product is guaranteed 6 months from the date of shipment.
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