MLL1 polyclonal, anti-human, mouse antibody
€310.00
In stock
SKU
AC-ABV10615-100
Catalog Number: AC-ABV10615-100
Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Size: 100 µl
Host: Rabbit IgG
Applications: WB
Datasheet
Request Information
Background:
Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromosome 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia, also designated ALL-1 and HRX) regulates embryonal and hematopoietic development.
Other Names:
MLL, MLL1, myeloid/lymphoid or mixed-lineage leukemia, HRX, TRX1, HTRX1, human trithorax 1, ALL-1, acute lymphocytic leukemia 1, CXXC7, HGNC:7132
Primary Accession: Q03164
Gene Name: KMT2A
Gene ID: 4297
Eukaryotic RNA polymerase II mediates the synthesis of mature and functional messenger RNA. This is a multistep process, called the transcription cycle, that includes five stages: preinitiation, promoter, clearance, elongation and termination. Elongation is thought to be a critical stage for the regulation of gene expression. ELL (11-19 lysine-rich leukemia protein, also designated MEN) functions as an RNA polymerase II elongation factor that increases the rate of transcription by suppressing transient pausing by RNA polymerase II. Also, ELL is thought to regulate cellular proliferation. ELL is abundantly expressed in peripheral blood leukocytes, skeletal muscle, placenta and testis, and has lower expression in spleen, thymus, heart, brain, lung, kidney, liver and ovary. The gene encoding human ELL, which maps to chromosome 19p13.1, is one of several genes which undergo translocation with the MLL gene on chromosome 11q23 in acute myeloid leukemia. MLL (myeloid/lymphoid leukemia, also designated ALL-1 and HRX) regulates embryonal and hematopoietic development.
Other Names:
MLL, MLL1, myeloid/lymphoid or mixed-lineage leukemia, HRX, TRX1, HTRX1, human trithorax 1, ALL-1, acute lymphocytic leukemia 1, CXXC7, HGNC:7132
Primary Accession: Q03164
Gene Name: KMT2A
Gene ID: 4297
| Is Featured? | No |
|---|
Write Your Own Review