MLLT1 Antibody (C-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP6188a
Background:
Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.
Other Names:
Protein ENL, YEATS domain-containing protein 1, MLLT1, ENL, LTG19, YEATS1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6188a was selected from the C-term region of human MLLT1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MLLT1
Gene ID: 4298
Primary Accession: Q03111
Other Accession: NP_005925
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Chromosome band 11q23 is the site of translocations in myeloid and lymphoid acute leukemias, pediatric leukemias, and treatment-induced secondary acute myelogenous leukemia. The translocation breakpoints cluster in a restricted region of the HRX gene resulting in chimeric genes that encode an N-terminal portion of Hrx fused to various partner proteins. Myeloid/lymphoid or mixed-lineage leukemia translocated to 1 (MLLT1) is a nuclear protein with transcriptional transactivation properties that is fused to Hrx in t(11;19) leukemias. The minimal MLLT1 sequence required for transcription activation was narrowed to the C-terminal 90 amino acids.
Other Names:
Protein ENL, YEATS domain-containing protein 1, MLLT1, ENL, LTG19, YEATS1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP6188a was selected from the C-term region of human MLLT1 . A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: MLLT1
Gene ID: 4298
Primary Accession: Q03111
Other Accession: NP_005925
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
| Is Featured? | No |
|---|
Write Your Own Review